Table 3.
Clinical and laboratory comparison between alcoholic liver disease cases with active alcoholism vs controls with no cirrhosis
| Patients (n = 26) | Controls (n = 27) | P value | |
| Age (yr) | 44.4 ± 14.4 | 47.4 ± 14.4 | |
| Men (%) | 88.5 | 14.8 | <0.0001 |
| WBC (× 109/L) | 6.9 ± 1.8 | 6.1 ± 1.4 | NS |
| Neutrophils (× 109/L) | 4.3 ± 1.5 | 3.4 ± 1.2 | 0.011 |
| RBC (× 1012/L) | 4.1 ± 0.7 | 4.5 ± 0.4 | NS |
| Hemoglobin (g/L) | 14.0 ± 4.0 | 13.9 ± 1.2 | NS |
| MCV (fL) | 99.9 ± 5.9 | 90.8 ± 4.0 | <0.0001 |
| Platelets (× 109/L) | 204.7 ± 84.6 | 231.0 ± 36.0 | NS |
| INR | 1.1 ± 0.2 | 1.0 ± 0.1 | NS |
| Creatinin (mg/dL | 0.9 ± 0.2 | 0.8 ± 0.1 | NS |
| Albumin (g/dL) | 4.0 ± 0.5 | 3.9 ± 0.6 | NS |
| Albumin/globulin ratio | 1.4 ± 0.3 | 1.4 ± 0.3 | NS |
| Alkaline phosphatase (UI/dL) | 102.3 ± 74.1 | 68.3 ± 14.0 | NS |
| GGT (UI/dL) | 297.8 ± 33.1 | 37.9 ± 33.1 | <0.0001 |
| ALT (UI/dL) | 55.8 ± 41.6 | 29.4 ± 15.3 | <0.0001 |
| AST (UI/dL) | 72.2 ± 52.8 | 25.1 ± 7.9 | <0.0001 |
| Total bilirubin (mg/dL) | 1.1 ± 0.6 | 0.7 ± 0.3 | 0.027 |
| CRP (mg/dL) | 1.1 ± 2.0 | 0.7 ± 0.7 | NS |
| Lymphocyte Subsets | |||
| Lymphocytes (× 109/L) | 1.8 ± 0.3 | 2.1 ± 0.5 | 0.018 |
| CD3+ lymphocytes (/mm3) | 1164.7 ± 376.6 | 1523.0 ± 364.6 | 0.001 |
| CD4+ lymphocytes (/mm3) | 759.8 ± 265.0 | 992.4 ± 274.7 | 0.003 |
| CD8+ lymphocytes (/mm3) | 330.9 ± 156.3 | 478.9 ± 164.6 | 0.002 |
| CD4+/CD8+ ratio | 2.5 ± 1.1 | 2.3 ± 0.9 | NS |
| CD19+ lymphocytes (/mm3) | 107.8 ± 64.2 | 264.6 ± 88.0 | <0.0001 |
| NK lymphocytes (/mm3) | 180.2 ± 169.0 | 178.7 ± 210.0 | NS |
WBC: White blood cell; RBC: Right blood cell; MCV: Mean cell volume; INR: International normalized ratio; GGT: γ-glutamyl transpeptidase; ALT: Alanine aminotransferase; AST: Aspartate transaminase; CRP: C-reactive protein; NK: Natural killer; NS: Not significant.