Table 4.
Clinical and laboratory comparison between alcoholic liver disease cases with cirrhosis but no active alcoholism and controls
| Patients (n== = 11) | Controls (n = 27) | P value | |
| Age (yr) | 56.8 ± 9.0 | 47.4 ± 14.4 | 0.03 |
| Men (%) | 100 | 14.8 | <0.0001 |
| MELD score | 10.5 ± 4.6 | - | |
| WBC (× 109/L) | 5.4 ± 2.5 | 6.1 ± 1.4 | NS |
| Neutrophils (× 109/L) | 3.4 ± 2.0 | 3.4 ± 1.2 | NS |
| RBC (× 1012/L) | 4.5 ± 0.4 | 4.5 ± 0.4 | 0.005 |
| Hemoglobin (g/L) | 12.9 ± 2.1 | 13.9 ± 1.2 | NS |
| MCV (fL) | 97.0 ± 6.0 | 90.8 ± 4.0 | 0.001 |
| Platelets (× 109/L) | 103.5 ± 39.4 | 231.0 ± 36.0 | <0.0001 |
| INR | 1.4 ± 0.3 | 1.0 ± 0.1 | <0.0001 |
| Creatinin (mg/dL) | 0.9 ± 0.3 | 0.8 ± 0.1 | NS |
| Albumin (g/dL) | 3.4 ± 0.7 | 3.9 ± 0.6 | 0.003 |
| Albumin/globulin ratio | 0.9 ± 0.3 | 1.4 ± 0.3 | <0.0001 |
| Alkaline phosphatase (UI/dL) | 124.9 ± 32.6 | 68.3 ± 14.0 | NS |
| GGT (UI/dL) | 84.2 ± 55.5 | 37.9 ± 33.1 | 0.005 |
| ALT (UI/dL) | 32.6 ± 7.6 | 29.4 ± 15.3 | NS |
| AST (UI/dL) | 46.9 ± 10.9 | 25.1 ± 7.9 | <0.0001 |
| Total bilirubin (mg/dL) | 2.2 ± 2.0 | 0.7 ± 0.3 | <0.0001 |
| CRP (mg/dL) | 1.1 ± 1.5 | 0.7 ± 0.7 | NS |
| Lymphocyte Subsets | |||
| Lymphocytes (×109/L) | 1.3 ± 0.6 | 2.1 ± 0.5 | <0.0001 |
| CD3+ lymphocytes (/mm3) | 954.5 ± 547.4 | 1523.0 ± 364.6 | 0.003 |
| CD4+ lymphocytes (/mm3) | 745.2 ± 389.0 | 992.4 ± 274.7 | 0.032 |
| CD8+ lymphocytes (/mm3) | 233.9 ± 120.0 | 478.9 ± 164.6 | <0.0001 |
| CD4+/CD8+ ratio | 3.5 ± 1.3 | 2.3 ± 0.9 | 0.01 |
| CD19+ lymphocytes (/mm3) | 150.8 ± 108.4 | 264.6 ± 88.0 | 0.001 |
| NK lymphocytes (/mm3) | 99.5 ± 54.5 | 178.7 ± 210.0 | NS |
MELD: Model for end-stage liver disease; WBC: White blood cell; RBC: Right blood cell; MCV: Mean cell volume; INR: International normalized ratio; GGT: γ-glutamyl transpeptidase; ALT: Alanine aminotransferase; AST: Aspartate transaminase; CRP: C-reactive protein; NK: Natural killer; NS: Not significant.