Table 2. List of SNPs of interest for HLA-DQB1*06:02 negative hypersomnias samples in Caucasian population.
| SNP(A/B) | Risk allele | RAF | HWE P-values | Chi-square 2-tailed P-values | OR | L95 | U95 | Nearest gene | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Case | Control | Case | Allelic | Dominant | Recessive | ||||||
| rs11854769 (C/T) | C | 0.731 | 0.732 | 0.369 | 0.263 | 9.70E-01 | 3.00E-01 | 6.20E-01 | 1.00 | 0.81 | 1.23 | SPRED1 |
| rs16966290(C/A) | A | 0.885 | 0.903 | 0.947 | 0.286 | 2.30E-01 | 7.70E-01 | 1.70E-01 | 1.20 | 0.88 | 1.63 | SPRED1 |
| rs12471007(C/G) | G | 0.035 | 0.040 | 0.179 | 0.501 | 5.50E-01 | 4.40E-01 | 4.50E-01 | 1.15 | 0.72 | 1.85 | NCKAP5 |
| rs10988217(G/A) | G | 0.597 | 0.648 | 0.581 | 0.456 | 2.51E-02 | 3.00E-02 | 1.16E-01 | 1.25 | 1.03 | 1.52 | CRAT |
Notes.
RAF: Risk allele frequency, HWE: Hardy-Weinberg Equilibrium, OR: Odds ratio, L95, U95: lower and upper limits of confidence interval at 95%.
Recessive model is calculated under risk allele homozygotes versus (heterozygous and non-risk homozygotes).
Dominant model is calculated under (risk allele homozygotes and heterozygotes) versus non-risk homozygotes.