. Author manuscript; available in PMC: 2013 Sep 1.

Published in final edited form as: Pediatr Res. 2012 Dec 7;73(3):362–370. doi: 10.1038/pr.2012.188

Table 6.

Odds ratio (and 99% confidence interval) of an MDI < 55 or an MDI 55–69 vs those with and MDI ≥ 70 among children who had the characteristics listed at the top of each column. The logistic regression models are adjusted for gestational age (23–24, 25–26, 27 weeks) and sex. The sample consisted of children who had a GMFCS < 1 and had proteins measured on 2 separate days (maximum N=805). The referent group consists of children who were not growth restricted at birth and who did not have two days of elevated concentrations of the protein listed on the left. Bold indicates odds ratios significantly > 1.0 (p < 0.01).

Protein	MDI^a < 55				MDI^a 55–69
	Protein concentration in top quartile on 2 separate days a week apart
	Yes		No		Yes		No
	SGA^b				SGA^b
	Yes	No	Yes	No	Yes	No	Yes	No
CRP	2.2 (0.5, 9.5)	3.2 (1.5, 6.7)	3.8 (1.6, 8.9)	1.0	1.6 (0.4, 7.1)	1.6 (0.7, 3.7)	1.5 (0.5, 4.2)	1.0
SAA	6.6 (1.6, 27)	3.3 (1.7, 7.1)	2.7 (1.1, 6.5)	1.0	1.7 (0.2, 13)	2.2 (1.01, 5.0)	1.6 (0.6, 4.2)	1.0
MPO	2.6 (0.5, 14)	1.1 (0.5, 2.6)	2.6 (1.2, 5.9)	1.0	0.7 (0, 9.8)	0.7 (0.3, 1.8)	1.5 (0.6, 3.7)	1.0
IL-1β	4.7 (1.2, 19)	1.7 (0.7, 3.8)	2.4 (1.02, 5.7)	1.0	1.4 (0.2, 10)	1.0 (0.4, 2.6)	1.4 (0.6, 3.7)	1.0
IL-6	6.9 (2.3, 21)	1.9 (0.9, 4.4)	1.7 (0.6, 4.6)	1.0	2.2 (0.5, 9.6)	1.1 (0.4, 2.7)	1.3 (0.5, 3.4)	1.0
IL-6R	2.3 (0.4, 13)	1.3 (0.6, 2.8)	2.7 (1.2, 6.2)	1.0	1.8 (0.3, 10)	0.8 (0.3, 1.9)	1.3 (0.5, 3.3)	1.0
TNF-α	6.9 (2.0, 24)	2.0 (0.9, 4.6)	2.1 (0.9, 4.3)	1.0	3.5 (0.8, 14)	1.5 (0.7, 3.5)	1.1 (0.4, 3.2)	1.0
TNF-R1	1.2 (0.2, 8.9)	1.1 (0.5, 2.6)	3.0 (1.3, 6.7)	1.0	2.6 (0.6, 10)	0.6 (0.2, 1.7)	1.0 (0.4, 2.9)	1.0
TNF-R2	2.5 (0.4, 14)	1.8 (0.8, 4.0)	2.9 (1.3, 6.6)	1.0	3.3 (0.7, 15)	1.9 (0.9, 4.1)	1.3 (0.5, 3.6)	1.0
IL-8 (CXCL8)	5.7 (1.7, 19)	2.4 (1.1, 5.5)	2.3 (0.9, 5.6)	1.0	1.2 (0.2, 8.7)	2.1 (0.9, 4.8)	1.7 (0.7, 4.5)	1.0
MCP-1 (CCL2)	2.8 (0.8, 10)	1.3 (0.6, 3.1)	2.6 (1.1, 6.3)	1.0	1.3 (0.2, 6.6)	1.0 (0.4, 2.5)	1.5 (0.6, 3.9)	1.0
MCP-4 (CCL13)	1.9 (0.4, 8.2)	0.8 (0.3, 2.0)	2.6 (1.1, 6.1)	1.0	1.1 (0.2, 5.8)	0.6 (0.2, 1.5)	1.4 (0.5, 3.6)	1.0
MIP-1β (CCL4)	6.3 (1.4, 29)	2.0 (0.95, 4.3)	2.6 (1.1, 6.1)	1.0	5.3 (1.2, 24)	1.5 (0.7, 3.2)	1.1 (0.4, 3.1)	1.0
RANTES (CCL5)	5.6 (0.9, 36)	1.3 (0.6, 2.8)	2.5 (1.1, 5.5)	1.0	1.2 (0.1, 20)	0.7 (0.3, 1.7)	1.3 (0.5, 3.3)	1.0
I-TAC (CXCL11)	2.3 (0.4, 13)	1.0 (0.4, 2.4)	2.5 (1.1, 5.7)	1.0	2.8 (0.7, 11)	0.4 (0.1, 1.3)	1.0 (0.3, 2.7)	1.0
ICAM-1 (CD54)	4.1 (1.2, 14)	2.6 (1.2, 5.6)	2.8 (1.1, 6.8)	1.0	1.4 (0.3, 7.1)	1.5 (0.6, 3.4)	1.6 (0.6, 4.2)	1.0
ICAM-3 (CD50)	1.7 (0.2, 13)	1.6 (0.8, 3.3)	3.1 (1.4, 6.9)	1.0	1.2 (0.2, 8.9)	0.6 (0.2, 1.6)	1.3 (0.5, 3.4)	1.0
VCAM-1 (CD106)	3.3 (0.7, 16)	1.4 (0.7, 3.1)	2.7 (1.2, 6.2)	1.0	2.0 (0.4, 11)	0.8 (0.3, 1.8)	1.2 (0.5, 3.2)	1.0
E-SEL (CD62E)	4.4 (1.2, 17)	2.2 (1.03, 4.7)	2.7 (1.1, 6.5)	1.0	3.1 (0.8, 12)	1.5 (0.7, 3.4)	1.2 (0.4, 3.4)	1.0
MMP-1	2.7 (0.5, 16)	0.7 (0.3, 1.8)	2.3 (1.04, 5.3)	1.0	2.3 (0.4, 14)	0.6 (0.3, 1.5)	1.2 (0.4, 3.0)	1.0
MMP-9	1.3 (0.1, 21)	0.8 (0.3, 2.1)	2.6 (1.2, 5.6)	1.0	1.2 (0.1, 19)	0.7 (0.3, 1.8)	1.4 (0.6, 3.3)	1.0
VEGF	1.3 (0.1, 21)	1.5 (0.7, 3.0)	3.0 (1.3, 6.7)	1.0	0.8 (0.1, 12)	0.4 (0.2, 1.1)	1.3 (0.5, 3.2)	1.0
VEGF-R1	2.1 (0.5, 8.2)	0.6 (0.2, 1.8)	2.5 (1.1, 5.9)	1.0	2.7 (0.8, 8.9)	0.8 (0.3, 2.0)	0.9 (0.3, 2.8)	1.0
VEGF-R2	2.2 (0.4, 12)	2.4 (1.2, 5.0)	3.4 (1.5, 7.8)	1.0	2.2 (0.5, 9.9)	1.0 (0.4, 2.4)	1.2 (0.5, 3.4)	1.0
IGFBP-1	4.9 (1.7, 15)	2.0 (0.9, 4.8)	2.0 (0.8, 5.3)	1.0	1.9 (0.5, 7.3)	0.9 (0.3, 2.6)	1.2 (0.4, 3.5)	1.0

Bayley Scales of Infant Development Mental Developmental Index when Gross Motor Function Classification System < 1

Birth weight below the 10^th percentile for gestational age.