Fig. 4.

Pharmacokinetic/pharmacodynamic properties of PC1001 4b. a) Organ and tissue distribution of PC1001 at various time points (6, 24, and 48 h pi) and via different administration routes (ip vs. iv) (n=4 per group). Top inset, blood clearance profile of PC1001. Equation y = y₀ + A₁× exp[−(x-x₀)/t₁ was used to fit the data points and the blood half-life was calculated to be 4.3±0.2 h (n=3) (R² = 0.9794 by Origin). b) Blood distribution of PC1001 at 6 h pi suggested that about 90% of probe was binding to serum instead of red blood cells (RBC) (n=3). c) Representative linear correlation (R²=0.9837 by Origin) of PC1001 uptake by tumor radioactivity with tumor weight within a single mouse after 48 h.