Table 3.

Familial aggregation of co-morbid anxiety disorders in the major depressive disorder sample^a

	Diagnosis in relatives
Relative diagnosis	Proband with anxiety disorder, n (%)	Proband without anxiety disorder, n (%)	aOR1b (95% CI)	p	aOR2c (95% CI)	p	aOR3d (95% CI)	p
Panic disorder	99/250 (39.6)	179/801 (22.4)	2.32 (1.69–3.19)	<0.001	2.22 (1.60–3.07)	<0.001	1.98 (1.41–2.78)	<0.001
Social phobia	30/137 (21.9)	133/914 (14.6)	1.58 (0.99–2.53)	0.057	1.40 (0.86–2.30)	0.18	1.32 (0.80–2.19)	0.28
Specific phobia	22/104 (21.2)	85/947 (9.0)	2.93 (1.69–5.10)	<0.001	2.42 (1.36–4.33)	0.003	2.43 (1.35–4.38)	0.003
OCD	14/66 (21.2)	76/985 (7.7)	2.88 (1.49–5.56)	0.002	2.64 (1.36–5.15)	0.004	2.60 (1.29–5.24)	0.008

aOR, Adjusted odds ratio; CI, confidence interval; OCD, obsessive-compulsive disorder.

^aAll relatives with recurrent MDD diagnosis.

^bAdjusted for age at interview, site of ascertainment, and sex.

^cAdjusted for age at interview, site of ascertainment, sex, and additional anxiety disorder co-morbidity in relatives.

^dAdjusted for age at interview, site of ascertainment, sex, and additional anxiety disorder co-morbidity in relatives and probands.