Figure 4.

ATX reduces lidocaine inhibition of CA3 Na currents. A, B, Na currents elicited in CA3 cells in 150 mm extracellular Na, in control (A) or in ATX (B). Conditioning voltage: thin black line, −30 mV; gray line, 0 mV; thick black line, +60 mV. C, Na channel availability during test step, normalized to reference in control without lidocaine (gray) or with lidocaine (black). Control, solid lines, ATX (dotted lines). D, Percentage lidocaine inhibition (baseline-subtracted) in control (black, n = 7) and ATX (dotted, n = 7).