Figure 8.

Low sensitivity of Purkinje neurons to lidocaine inhibition. A, Sample traces from a Purkinje neuron, in control (left) and in ATX (right), in 50 mm extracellular Na. Conditioning steps: thin black line, −30 mV; gray line, 0 mV; thick black line, +60 mV. B, Percentage lidocaine inhibition after 100 μm (triangles, n = 5) or 1 mm (squares) lidocaine for Purkinje cells (black, n = 5). Data from peptide-free CA3 cells from other figures are included in gray for comparison. C, Percentage of lidocaine inhibition recorded without (up triangles, n = 5) and with (down triangles, n = 5) ATX versus delay of lidocaine onset relative to the conditioning step.