FIG. 4.

Effect of 1% SAR 1118 on S. aureus-induced neutrophil recruitment and on epithelial cell apoptosis. Corneas were treated with 1% SAR 1118 before inducing inflammation by incubating 2 h with tobramycin-killed S. aureus in the presence of a contact lens. After 24 h, eyes were processed for histology, and 5-μm sections were immunostained with NIMP-R14 and counterstained with DAPI (A), or were stained with TUNEL reagents, counterstained with DAPI. Images are representative of 5 mice per group (B). Epi, corneal epithelium. Original magnification is×400. Color images available online at www.liebertpub.com/jop