Table 1.

Effect of Lifitegrast (SAR 1118) on Corneal Inflammation

Expt	Inoculum	Group	Number of mice	Time of applicationsa	Neutrophils/section	% inhibition	P
1	PA	Vehicle	3	−15 h, −3 h, −1 h	348.0
		5% SAR 1118	3		195.7	46	0.01
2	PA	Vehicle	4	−15 h, −3 h	376.5
		1% SAR 1118	3		171.3	53	0.001
		0.1% SAR 1118	3		158.7	48	0.001
3	PA	Vehicle	5	−15 h, −3 h, −1 h	359.8
		5% SAR 1118	5		271.2	23	0.01
		1% SAR 1118	5		211.8	42	0.001
		0.1% SAR 1118	5		241.4	35	0.01
4	PA	Vehicle	3	−15 h, −3 h	385.3
		0.1% SAR 1118	3		275.0	36	0.015
		1% SAR 1118	4		162.0	62	0.004
		5% SAR 1118				35	0.016
5	SA	Vehicle	4	−15 h, −3 h	242.0
		1% SAR 1118	4		112.0	53	0.005
6	PA	Vehicle	3	−1 h, +1 h	373.3	0
		1% SAR 1118	3		336.7		0.398
7	PA	Vehicle	5	−1 h, +1 h	245.8	28
		0.1% SAR 1118	5		175.8		0.206
8	PA	Vehicle	4	−1 h, +1 h	445.3	0
		5% SAR 1118	3		494.3		−0.227

^abefore or after corneal abrasion and stimulation with P. aeruginosa or S. aureus.

PA, Pseudomonas aeruginosa; SA, Staphylococcus aureus; NS, not significant (P>0.05).