Table I.
MiR-93 expression, NRF2 protein expression and tumor incidence in female ACI rats after different treatments
| Treatment | n | Pri-miR-93 expression (fold change versus control) | NRF2 protein expression (fold change versus control) | Tumor incidence (%) |
|---|---|---|---|---|
| Control | 10 | 1.00 | 1.00 | 0 |
| E2 | 11 | 1.68* | 0.61* | 82 |
| Tumor | 11 | 1.87* | 0.35* | — |
| Vit C | 17 | 0.71 | 2.53* | 0 |
| Vit C + E2 | 17 | 0.80 | 2.36* | 29** |
MiR-93 expression and NRF2 protein expression levels were measured in mammary tumors and in mammary tissues from control, E2-, vit C- and vit C + E2-treated rats after 240 days of treatment. Column one lists the different treatments each group of animals received. The number of animals per group (n) is listed in column two. Columns three and four show the pri-miR-93 expression and NRF2 protein expression, respectively, as an average of values obtained for at least five different animals. The percent tumor incidence in each treatment group after 240 days of treatment is listed in column five.
*P < 0.05 compared with control tissue.
**P < 0.05 compared with E2-treated group.