Table III.
Genes significantly associated with risk of ESCC in the overall sex hormone pathway in the combined population
| Gene | Location | Gene.P◊ | Total number of tag SNPs | No. of SNPs with P < 0.05 (%) | Most significant SNP (major/minor allele) | Most significant SNP* | ||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P n | ||||||
| SULT2B1 | 19q13.3 | 0.013 | 22 | 2 (9%) | rs4149455 (C/T) | 0.81 | 0.72–0.92 | 0.0007 |
| CYP1B1 | 2p21 | 0.019 | 30 | 1 (3.3%) | rs9341266 (G/A) | 1.45 | 1.16–1.82 | 0.001 |
| CYP3A7 | 7q21–q22.1 | 0.030 | 2 | 1 (50%) | rs2005548 (C/T) | 1.17 | 1.03–1.32 | 0.019 |
| CYP3A5 | 7q21.1 | 0.034 | 8 | 4 (50%) | rs17161780 (G/A) | 1.19 | 1.04–1.35 | 0.009 |
| SHBG | 17p13-p12 | 0.037 | 5 | 3 (60%) | rs727428 (T/C) | 0.86 | 0.76–0.96 | 0.010 |
| CYP11A1 # | 15q23-q24 | 0.038 | 15 | 1 (7%) | rs2277604 (G/T) | 1.45 | 1.13–1.90 | 0.004 |
Gene-based P values (P◊) were calculated using the ARTP method. SNP* OR and nominal P values (P n) were obtained from unconditional logistic regression. Per allele ORs and nominal P values for SNPs were obtained from unconditional logistic regression and were adjusted by age, sex and geographical location. CYP11A1 rs2277604 was analyzed using a dominant model (#), whereas the remaining SNP ORs are per allele ORs.