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. 2012 Apr 4;32(14):4762–4772. doi: 10.1523/JNEUROSCI.3560-11.2012

Figure 2.

Figure 2.

Interneurons in cortex are generated independently of cortical astrocytes. Approximately 5% of adult TFC.09 × Z/EG mice exhibited widely distributed GFP+ cells within cortex that were not arranged in columns (A). In these mice, GFP+ cells were distributed sparsely in layers 2 through 6 of neocortex through the entire anteroposterior and mediolateral axes (A, B). The GFP+ cells in cortex of these mice displayed the characteristic morphologies of interneurons, with fine local processes (C). The cortices of these mice did not contain labeled astrocytes (C). TFC.09 × Z/EG mice with interneurons in cortex always had GFP+ cells broadly distributed through their ipsilateral striatum (A, B, D). In mice with GFP+ interneurons in cortex, the striatum contained both GFP+ neurons and astrocytes (D). In the striata of these mice, GFP+ neurons and astrocytes had the characteristic morphologies of medium spiny interneurons and protoplasmic astrocytes, respectively (D). C and D are high-magnification views of the insets labeled “C” and “D” in B. B is a higher-magnification view of the inset in A. Scale bars: A, 500 μm; B, 250 μm; C, D, 50 μm.