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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Clin Pharmacol Ther. 2012 Aug 1;92(3):287–290. doi: 10.1038/clpt.2012.114

Figure 2.

Figure 2

Chemical structures of small-molecule CFTR inhibitors. Top: original (pre-high–throughput screening) CFTR inhibitors. Center: absorbable CFTR inhibitors acting at the CFTR cytoplasmic surface. Bottom: externally acting hydrazide-class CFTR inhibitors. BPO, benzopyrimido-pyrrolo-oxazine-dione; CFTR, cystic fibrosis transmembrane conductance regulator; DPC, diphenylamine-2-carboxylate; NPPB, 5-nitro-2-(3-phenylpropyl-amino)benzoate; PPQ, pyrimido-pyrrolo-quinoxalinedione.