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. 2013 Mar 21;41(9):5104–5114. doi: 10.1093/nar/gkt146

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Structure of ternary complex (PolIV_dA:dTMPnPP). (A) The structure of PolIV is displayed in ribbon representation with the palm domain coloured cyan, fingers domain coloured yellow, thumb domain coloured orange, PAD domain coloured green and linker between Thumb and PAD domain coloured wheat. DNA is displayed in stick representation, and atoms are coloured according to element. The template and incoming nucleotide—dA and dTMPnPP—are coloured according to element. The Mg²⁺ ions are shown in the form of blue spheres. (B) Active site of PolIV. A close up of the active site of PolIV_dA:dTMPnPP is shown with the residues that form interactions with the template dA (G33, R38, G39, V40, S42, A56, T248, K291, F295 and R330) and incoming dTMPnPP (D8, M9, D10, C11, F12, F13, S42, T43, R49, S55, D103 and K157) displayed in stick representation. DNA residues and incoming nucleotide are also displayed in stick representation, and all the residues are coloured according to constituent elements. The Mg²⁺ ions are shown in the form of a blue spheres.