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DMP12 partially prevents the DNA binding of Neisseria HU protein. A preliminary EMSA showed that the addition of 4 µM Neisseria HU protein produced a marked band shift of the 2.5 nM plasmid DNA substrate (Supplementary Figure S5), and this concentration was, therefore, used in this competitive EMSA assay. The results show that the DNA mimic DMP12 partially reduces the DNA shift of Neisseria HU in a dosage-dependent manner.
