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Effect of combined transfection with miR-15a and Bcl-2 siRNA plus MTX on the morphology of Raji cells at 48 h. Nuclear morphology of cells stained with Hoechst-33 258 was analyzed by fluorescence microscopy (×200) at 48 h after transfection. Data are representative microscopic pictures. Untreated cells (A); negative siRNA (B); MTX (C); negative siRNA + MTX (D); scrambled ODN + MTX (E); miR-15a ODN + MTX (F); Bcl-2 siRNA + MTX (G); and miR-15a ODN + Bcl-2 siRNA + MTX (H).
