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Rate of apoptosis induced by combined transfection with miR-15a and Bcl-2 siRNA plus MTX in Raji cells at 48 h. Apoptosis was analyzed by AnnexinV-FITC/PI staining at 48 h after treatment. Data are representative pictures. Untreated cells (A); negative siRNA (B); MTX (C); negative siRNA + MTX (D); scrambled ODN + MTX (E); miR-15a ODN + MTX (F); Bcl-2 siRNA + MTX (G); and miR-15a ODN + Bcl-2 siRNA + MTX (H)
