Figure 4.

Sex and age effects: CTh changes associated with testosterone in pre- and postpubertal males and females. These graphs show a typical example of how sex and age modulated the relationship between testosterone and CTh. There was an increase in the CTh in the left posterior cingulate gyrus associated with testosterone in prepubertal females, a relationship that was reversed in postpubertal females (blue lines). Males showed a testosterone-related decrease in the CTh in the same area in both pre- and postpubertal subjects, although the strength of the association differed (green lines). CTh_PCC, cortical thickness of the left posterior cingulate gyrus; ln_testo, natural logarithm of testosterone.