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. Author manuscript; available in PMC: 2013 May 3.
Published in final edited form as: Comb Chem High Throughput Screen. 2011 Sep;14(8):669–687. doi: 10.2174/138620711796504442

Figure 4. Dose response of 6 confirmed Cdc7-Dbf4 kinase inhibitors.

Figure 4

The results of ADP production (●), ADP processing (▲), and luminescence detection (■) of the following 6 compounds in the LUM method are shown: (A). Iriginol hexaaceatate; (B). Hematein; (C). Caffeic acid; (D). Myricetin; (E). Ferulic acid; (F). Quercetin. The results of luminescence detection before each compound dilution was added are also shown (□). The results of ADP production are the Avg ± SE of 2 data points (n=2), and the results of ADP processing and luminescence detection are the Avg ± SE of 3 data points (n=3). Dose response curve of the average was fitted by the logistic 4-parameter equation of SigmaPlot. Solid lines show the curve fit of ADP production. The IC50 values of ADP production of each compound are as follows: (A). Iriginol hexaaceatate, 1.01±0.04 μM; (B). Hematein, 3.13±0.36 μM; (C). Caffeic acid, 6.19±0.42 μM; (D). Myricetin, 12.04±2.55 μM; (E). Ferulic acid, 13.19±3.90 μM; (F). Quercetin, 59.71±28.56 μM.