. Author manuscript; available in PMC: 2013 May 3.

Published in final edited form as: Comb Chem High Throughput Screen. 2011 Sep;14(8):669–687. doi: 10.2174/138620711796504442

Table 3.

Dose response and solubility of the 20 active compounds in the primary screens.

Name	ADP production IC50 (μM)	ADP processing IC50 (μM)	Luminescence detection IC50 (μM)	Solubility	Use/Therapy
Iriginol hexaaceatate	1.01±0.04	N.E.¹	N.E.	Soluble	Semisynthetic compound. Has not been approved as a drug.
Hematein	3.13±0.36	N.E.	N.E.	Soluble	Anti-inflammatory and anti atherogenic effect in the rabbit model. Tested for the treatment of porphyria. Has not been approved as a drug.
Caffeic acid	6.19.±0.42	N.E.	N.E.	Soluble	A natural dietary phenolic compound found in plants that is an anti-oxidant. Inhibits the synthesis of leukotrienes. Inhibits carcinogenesis. Has not been approved as a drug.
Myricetin	12.04±2.55	N.E.	N.E.	Soluble	A naturally occurring flavonol with antioxidant properties. Reduced the risk of pancreatic cancer.
Ferulic acid	13.19±3.90	N.E.	N.E.	Soluble	Anti neoplastic, choleretic, food preservative. Tested for Alzheimer disease in Japan. Has not been approved as a drug.
Quercetin	59.71±28.56	N.E.	N.E.	Soluble	Anti tumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Reduced the risk of pancreatic cancer.
Ellagic acid	0.77±0.06	Inhibits ATP depletion at higher concentration	N.E.¹	Soluble	Hemostatic, anti neoplastic, anti mutagenic. Anti proliferative and anti oxidant properties in animal models. Has not been approved as a drug.
Irigenol	1.15±0.07	Inhibits ATP depletion at higher concentration	N.E.	Soluble	Plant product. Has not been approved as a drug.
Epicatechin monogallate	33.66±7.55	Inhibits ATP depletion at higher concentration	N.E.	Soluble	Antioxidant polyphenol flavinoid. Inhibits Scrapie-associated prion formation. Has not been approved as a drug.
Epigallocatechin-3-monogallate	38.64±24.93	Inhibits ATP depletion at higher concentration	N.E.	Soluble	Antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. Inhibits Scrapie-associated prion formation. Has not been approved as a drug.
Tannic acid	0.77±0.24	Inhibits ATP depletion at higher concentration	N.E.	Soluble	Nonspecific enzyme/receptor blocker. A specific commercial form of tannin, a polyphenol that is commonly found in topical skin ointments.
Theaflavin monogallates	4.27±0.53	Inhibits ATP depletion at higher concentration	N.E.	Soluble	Black tea polyphenol. Inhibits growth of cancer cells but not normal cells. Has not been approved as a drug.gua
Gentian violet	12.81±2.57	9.47±0.58	10.31±1.01	Soluble	Anti bacterial, anthelmintic effect. Antiseptic to treat fungal infections of the skin.
Pararosaniline pamoate	14.94±4.66	9.04±0.82	11.64±1.89	Soluble	Anthelmintic, anti schistosomal drug.
Enalapril maleate	N.E.¹	N.E.	N.E.	Soluble	Angiotensin converting enzyme inhibitor. Anti hypertensive drug.
Fisetin	N.E.	N.E.	N.E.	Soluble	Anti oxidant, anti inflammatory, and anti carcinogenic effect. Has not been approved as a drug.
Hieracin	N.E.	N.E.	N.E.	Soluble	Known guaianolide. Has not been approved as a drug.
Iodipamide	N.E.	N.E.	N.E.	Soluble	Radioopaque agent. Used for diagnosis tests for the biliary excretion.
Purpurogallin	N.E.¹	N.E.	N.E.	Soluble	Plant phenol. Anti oxidant. Added to fats-oils, fuels, and lubricants as an oxidation retardant.
Pyrogallin	N.E.	N.E.	N.E.	Soluble	Anti infectant. Has not been approved as a drug.

N.E., no effect.