Table 1.
Study drugs for which mechanistic and clinical pharmacokinetic (PK) data will be generated
| Studies | Sedatives & analgesics | Antivirals /antifungals | Antibacterials |
|---|---|---|---|
| Ex vivo stability |
Morphine |
Fluconazole |
Ceftriaxone |
| Ex vivo circuits |
Morphine -3 -glucuronide |
Caspofungin |
Meropenem |
| Ovine ECMO |
Morphine -6 –glucuronide |
Vancomycin |
|
| Population PK |
Fentanyl, nor-fentanyl |
Ciprofloxacin |
|
| Midazolam |
Gentamicin* |
||
| 1 & 4 hydroxy midazolam | |||
| Ex vivo stability |
Propofol ,Thiopentone |
Oseltamivir |
Piperacillin/tazobactum Ticarcillin/clavulunate |
| Population PK | Dexmedetomidine | Voriconazole | Cefepime, Linezolid |
OC –oseltamivir carboxylate. * Gentamicin will not included in the ex vivo circuit studies due to its incompatibility with other study drugs.