Table 2.
Details of recurrence patterns and salvage treatments
| Patient no. |
Patterns of recurrence |
Salvage treatmentb |
Current status | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Initial |
Cumulativea |
|||||||||
| Central | In-field | Marginal | Out-field | Distant | Surgery | SRT | Chemo | |||
| 1 |
Distant |
- |
- |
- |
- |
- |
0 |
0 |
- |
Dead |
| 2 |
Central |
3 |
0 |
1 |
0 |
2 |
Central (1) |
Central(1) |
ICE, BEV |
Dead |
| Marginal (1) | ||||||||||
| 3 |
Distant |
- |
- |
- |
- |
- |
0 |
0 |
ICE |
Dead |
| 4 |
Out-field |
0 |
0 |
0 |
2 |
0 |
0 |
Out-field (2) |
ICE, BEV, Others |
Dead |
| 5 |
Central |
1 |
0 |
0 |
0 |
1 |
Central (2) |
Central (1) |
ICE |
Dead |
| 6 |
Central |
1 |
0 |
0 |
0 |
0 |
Central (2) |
0 |
ICE |
Dead |
| 7 |
Central |
2 |
0 |
1 |
0 |
2 |
Central (2) |
Central (1) |
ICE, BEV, Others |
Dead |
| 8 |
Central |
2 |
0 |
0 |
0 |
1 |
0 |
0 |
ICE, BEV |
Dead |
| 9 |
In-field |
1 |
0 |
1 |
2 |
1 |
Central + In-field (1) |
Marginal (1) |
ICE, BEV |
Dead |
| 10 |
Central |
0 |
1 |
0 |
1 |
1 |
Central (1) |
0 |
ICE, BEV |
Dead |
| 11 |
Central |
2 |
1 |
0 |
0 |
1 |
Central (1) |
Central (2) |
ICE, BEV, Others |
Dead |
| In-field (1) | ||||||||||
| 12 |
Out-field |
0 |
0 |
0 |
2 |
1 |
0 |
Out-field (1) |
ICE, BEV |
Alive |
| 13 |
Central |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
ICE |
Dead |
| 14 |
Central |
2 |
0 |
0 |
0 |
1 |
Central (2) |
Central (1) |
ICE, BEV |
Dead |
| 15 |
In-field |
- |
- |
- |
- |
- |
0 |
In-field (1) |
- |
Alive |
| 16 |
Central, In-field |
1 |
1 |
0 |
0 |
1 |
Central (1) |
Central + |
ICE, BEV |
Dead |
| In-field (1) | ||||||||||
| 17 |
Central, Distant |
- |
- |
- |
- |
- |
0 |
0 |
- |
Dead |
| 18 |
Central |
1 |
1 |
0 |
0 |
1 |
Central (1) |
0 |
ICE |
Dead |
| In-field (1) | ||||||||||
| 19 |
Central |
1 |
0 |
0 |
0 |
1 |
Central (2) |
0 |
ICE |
Dead |
| 20 |
In-field |
0 |
1 |
0 |
1 |
1 |
0 |
In-field (1) |
ICE, Others |
Alive |
| In-field + Out-field + Distant (1) | ||||||||||
| 21 | Central, Distant | - | - | - | - | - | 0 | 0 | - | Dead |
BEV: bevacizumab.
ICE: ifosfamide, carboplatin, and etoposide.
SRT: stereotactic radiotherapy.
aCumulative recurrence patterns were classified and counted each time a new recurrent lesion was detected in follow-up MRI scans after the initial recurrence. Five patients had no scans after the initial recurrence and were excluded from the analysis of cumulative recurrence.
bRegarding local salvage, recurrence patterns of treated lesions are described; repeat local salvage numbers are also indicated.