Table 3. Cytokine, chemokine, receptor, adhesion molecule, and PrP gene expression levels.
Molecule | Histological pattern | P-value (P-value <0.05)* | ||||||||
Lymphofollicular | Lymphoproliferative/non-lymphofollicular | Granulomatous | Healthy | L vs LnL | L vs G | L vs H | LnL vs G | LnL vs H | G vs H | |
LTα | 62.83±43.99 | 10.06±16.24 | 4.42±4.82 | 2.21±1.82 | 0.0031 | 0.0012 | 0.0001 | 0.9761 | 0.6406 | 0.8769 |
LTβ | 207.03±198.98 | 14.56±22.34 | 9±11.36 | 2.62±3.51 | 0.0013 | 0.0006 | 0.0000 | 0.9845 | 0.2660 | 0.4530 |
TNFα | 78.91±85.08 | 24.26±47.44 | 17.71±25.82 | 2.75±3.9 | 0.0711 | 0.1322 | 0.0017 | 0.9888 | 0.4973 | 0.3174 |
LTBR | 2.8±1.73 | 1.9±2.47 | 2.41±0.47 | 0.92±0.81 | 0.4562 | 0.9988 | 0.0567 | 0.5756 | 0.7172 | 0.0991 |
TNFR1 | 4.16±2.26 | 1.98±1.93 | 2.28±0.4 | 1.14±1.05 | 0.1490 | 0.5234 | 0.0095 | 0.8462 | 0.6902 | 0.2273 |
CCL19 | 236.49±175.91 | 29.29±51.87 | 20.98±24.8 | 2.81±5.77 | 0.0160 | 0.0366 | 0.0001 | 0.9813 | 0.2878 | 0.1476 |
CCL21 | 6.46±4.59 | 3.37±3.63 | 0.95±0.26 | 1.2±1.75 | 0.3001 | 0.0270 | 0.0079 | 0.6057 | 0.9920 | 0.3872 |
CXCL12 | 2.96±1.55 | 1.62±1.69 | 2.45±0.38 | 0.61±0.9 | 0.1965 | 0.9811 | 0.0015 | 0.3881 | 0.2034 | 0.0059 |
CXCL13 | 634.69±522.43 | 25.41±42.71 | 134.97±240.91 | 7.81±19.04 | 0.0022 | 0.0792 | 0.0001 | 0.3986 | 0.0391 | 0.6356 |
CCR7 | 62.72±33.66 | 10.22±15.33 | 9.18±8.41 | 2.46±5.09 | 0.0046 | 0.0096 | 0.0000 | 0.9882 | 0.1955 | 0.1057 |
CXCR4 | 22.3±19.19 | 5.55±10.19 | 3.34±1.27 | 0.98±1.48 | 0.0213 | 0.0596 | 0.0004 | 0.9629 | 0.4747 | 0.2280 |
CXCR5 | 50.98±45.78 | 3.74±4.68 | 3.11±1.85 | 2.57±2.29 | 0.0003 | 0.0004 | 0.0000 | 0.9977 | 0.9783 | 0.9321 |
VCAM1 | 32.54±51.84 | 2.41±3.24 | 7.93±6.48 | 1.03±2.15 | 0.0094 | 0.4340 | 0.0004 | 0.2322 | 0.7084 | 0.0220 |
LYVE1 | 1.73±1.47 | 0.44±0.75 | 0.3±0.13 | 0.16±0.09 | 0.0398 | 0.0330 | 0.0048 | 0.9998 | 0.8999 | 0.9320 |
PrP | 3.42±4.39 | 1.02±1.45 | 17.02±4.99 | 1.13±1.56 | 0.3832 | 0.0012 | 0.3636 | 0.0001 | 0.0000 | 0.9996 |
For the different groups the data are shown as mean values ± SD. Multiple comparisons were made with Tukey’s test.
P<0.05 values were considered to be statistically significant.
L = lymphofollicular; LnL = lymphoproliferative/non-lymphofollicular; G = granulomatous; H = healthy.