Table 2. Associations of PON1 with Obesity Parameters at Ages 2 and 5.
| Age 2 | Age 5 | |||||||
| N | β or OR(95% CI) | p-valuec | r2 | N | β or OR(95% CI) | p-value | r2 | |
| BMI Z score | ||||||||
| Model 1 | ||||||||
| PON1192 a | 360 | 0.25(0.07,0.42) | 0.01 | 0.02 | 311 | 0.15(−0.03,0.33) | 0.10 | 0.01 |
| Model 2 | ||||||||
| ARYaseb | 243 | 0.19(0.04,0.33) | 0.01 | 0.05 | 215 | 0.04(−0.11,0.19) | 0.59 | 0.01 |
| PON1192 | 0.20(−0.01,0.40) | 0.06 | 0.11(−0.10,0.32) | 0.32 | ||||
| Waist Circumference | ||||||||
| Model 1 | ||||||||
| PON1192 | 311 | 1.30(0.09,2.51) | 0.04 | 0.01 | ||||
| Model 2 | ||||||||
| ARYase | 215 | 1.89(−0.04,3.81) | 0.05 | 0.03 | ||||
| PON1192 | 4.61(−0.68,9.90) | 0.09 | ||||||
| ARYase × PON1192 | −0.98(−2.33,0.36) | 0.15 | ||||||
| Obesity Status | ||||||||
| Model 1 | ||||||||
| PON1192 | 360 | 2.41(1.54,3.76) | 0.0001 | 311 | 1.55(1.10,2.18) | 0.01 | ||
| Model 2 | ||||||||
| ARYase | 243 | 1.58(1.07,2.32) | 0.02 | 215 | 1.73(0.87,3.46) | 0.12 | ||
| PON1192 | 1.87(1.09,3.22) | 0.02 | 5.05(0.79,32.33) | 0.09 | ||||
| ARYase × PON1192 | 0.70(0.44,1.11) | 0.13 | ||||||
a
PON1192 coded as number of Q alleles, 0, 1 or 2.
b
Children were considered obese if their BMI was at or above 95th percentile of the 2000 CDC sex-specific BMI-for-age growth charts.
c
Using a Bonferonni correction for multiple testing (5 tests per model), we considered p-values less than 0.01 to be statistically significant.
Model 1 examines the association of PON1192 only with obesity parameters. Model 2 examines the association of PON1 status with obesity parameters by including both ARYase and PON1192.