Table 3. Associations of Child PON1 and Genetic Ancestry with Obesity Parameters at Ages 2 and 5.
Age 2 | Age 5 | |||||||
N | β or OR(95% CI) | p-valued | r2 | N | β or OR(95% CI) | p-value | r2 | |
BMI Z-score | ||||||||
ARYase | 243 | 0.19(0.04,0.33) | 0.011 | <0.005 | 215 | 0.05(−0.10,0.21) | 0.517 | 0.01 |
PON1192 a | 0.17(−0.03,0.38) | 0.102 | 0.10(−0.11,0.32) | 0.345 | ||||
% European Ancestry | 0.13(−0.96,1.21) | 0.815 | −0.17(−1.36,1.02) | 0.781 | ||||
% African Ancestryb | 0.16(−0.10,0.41) | 0.223 | 0.18(−0.11,0.47) | 0.225 | ||||
Waist Circumference | ||||||||
ARYase | 215 | 2.00(0.05,3.94) | 0.044 | 0.04 | ||||
PON1192 | 4.75(−0.57,10.08) | 0.080 | ||||||
ARYase × PON1192 | −1.03(−2.38,0.32) | 0.135 | ||||||
% European Ancestry | −1.46(−8.96,6.05) | 0.702 | ||||||
% African Ancestry | 1.03(−0.79,2.85) | 0.266 | ||||||
Obesity Statusc | ||||||||
ARYase | 243 | 1.58(1.07,2.34) | 0.021 | 215 | 1.75(0.88,3.52) | 0.113 | ||
PON1192 | 1.91(1.09,3.34) | 0.024 | 5.16(0.80,33.11) | 0.084 | ||||
ARYase × PON1192 | 0.69(0.44,1.11) | 0.125 | ||||||
% European Ancestry | 0.18(0.01,3.32) | 0.250 | 0.71(0.07,7.24) | 0.770 | ||||
% African Ancestry | 1.57(0.78,3.14) | 0.203 | 1.10(0.62,1.96) | 0.735 |
PON1192 coded as number of Q alleles, 0, 1 or 2.
Proportional African ancestry was log transformed to normalize the distribution.
Children were considered obese if their BMI was at or above 95th percentile of the 2000 CDC sex-specific BMI-for-age growth charts.
Using a Bonferonni correction for multiple testing (5 tests per model), we considered p-values less than 0.01 to be statistically significant.