Table 2.
Brain Regions Demonstrating Increased and Decreased (p<0.001) Regional Cerebral Blood Flow (rCBF) Following Ondansetron Compared with Saline in Early-onset and Late-onset Cocaine-dependent Subjects
| Identified ROI | MNI coordinates | kE1 | ||
|---|---|---|---|---|
| x | y | z | ||
| Early-onset | ||||
| Increased rCBF | ||||
| Subthalamic nucleus, right | 18 | −16 | −6 | 94 |
| ACC (BA32) | 4 | 42 | 2 | 66 |
| Inferior temporal gyrus, left | −46 | −72 | −16 | 73 |
| Parahippocampal gyrus, right | 26 | −38 | −12 | 55 |
| Decreased rCBF | ||||
| Superior mid-frontal gyrus, right | 18 | 38 | 30 | 143 |
| Inferior parietal lobule, right | 38 | −34 | 34 | 74 |
| Late-onset Cocaine-Addicted | ||||
| Increased rCBF | ||||
| Anterior cingulate | −18 | 28 | 26 | 93 |
| Decreased rCBF | ||||
| Middle temporal gyrus, left (BA21) | −68 | −30 | 0 | 52 |
| Insula, left (BA13) | −36 | 2 | 10 | 95 |
| Parahippocampal gyrus, right | 26 | −36 | −8 | 65 |
1
Cluster size