Table 3.

Brain Regions Demonstrating Increased and Decreased (p<0.001) Regional Cerebral Blood Flow (rCBF) Following Ondansetron Compared with Saline in Early-onset vs. Late-onset Cocaine-dependent vs. Healthy Control Participants

Identified ROI	MNI coordinates			kE1
	x	y	z
Early-onset vs. Late-Onset
Increased rCBF in Early vs Late
Parahippocampal gyrus, right	26	−36	−8	114
Subthalamic nucleus, right	18	−16	−6	83
Insula, left	−36	2	12	93
Decreased rCBF in Early vs. Late
Superior frontal gyrus, right	18	38	30	163
Inferior parietal lobule, right (BA40)	48	−34	34	64
Early-onset vs. Controls
Increased rCBF
Subthalamic nucleus, right	18	−16	−6	141
Lingual gyrus, right	8	−68	−2	87
Anterior cingulate, BA32	4	42	2	100
Parahippocampal gyrus, right	34	−38	−12	67
Lateral occipital gyri (BA19), left	−44	−68	−12	62
Decreased rCBF
Superior frontal gyrus, right	18	38	32	83
Late-onset vs. Controls
Increased rCBF
Anterior cingulate	−16	28	28	85
Decreased rCBF
Insula, left	−36	4	14	161
Parahippocampal gyrus, right	28	−36	−4	84

¹Cluster size