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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Cancer Res. 2013 Apr 22;73(9):2718–2736. doi: 10.1158/0008-5472.CAN-12-4213

Figure 2. Prostatic intraepithelial neoplasia (PIN) in GEM mouse models.

Figure 2

A. Low grade mPIN in 73 week old wild type mouse. Arrow shows focal epithelial proliferation with mild atypia. B. Low grade mPIN in Pten null model (K5 promoter) 12 week old mouse C. High grade mPIN in Pten null model (K14 promoter). Note central necrosis and proliferation of atypical cells filling the duct but with well demarcated border (medium power). Chronic inflammation is noted (arrow). D. High grade mPIN in Pten null model. Arrow shows nucleus with striking pleomorphic atypia.