Figure 1. A new Wnt/β-catenin signaling model based on the study from Li et al.²⁷ (A) In the absence of Wnt protein (Off State), the destruction complex (Axin, GSK3, CK1, APC and Dvl) resides in the cytoplasm, where it binds, phosphorylates, and ubiquitinates β-catenin by β-TrCP. The proteasome recycles the complex by degrading β-catenin. (B) In the presence of Wnt (On State), this protein induces the association of the intact complex with phosphorylated LRP. After binding to LRP, the destruction complex stills captures and phosphorylates β-catenin, but ubiquitination by β-TrCP is blocked. Newly synthesized β-catenin accumulates (Adapted from Clevers and Nusse²).