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. 2013 Apr 30;4:1792. doi: 10.1038/ncomms2799

Figure 4. Response of the gene regulatory network to repeat stress episodes.

Figure 4

(a) Protein levels for GR, PXR, CYP3A4 and TAT, as well as free blood cortisol, were simulated over 21 days following addition of repeat spikes of cortisol, such that each spike doubled the free blood cortisol concentration. Frequency of cortisol spikes were 1 per week (grey line), 1 per day (black line) or 1 per hour (dashed line). (b) TAT and free blood cortisol were simulated as above, but under wild-type (black line) and GR/PXR stubborn (grey line) network variants.