Figure 6. TcpB promotes enhanced polyubiquitination of MAL.
293 cells were transfected with HA-MAL, VSV-Ubiquitin and TcpB using PEI. After 24 hrs, cells were treated with 20 mM MG132 where indicated for additional 4 hrs. Cell lysates were then immunoprecipitated with a-HA as described in methods and materials and immunoblotted with anti-VSV for detection of polyubiquitinated MAL.
