Table 3.
Univariate analysis of predictive factors for survival and recurrence
| overall survival | disease-free survival | distant metastasis | local recurrence | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95 % CI | p | HR | 95 % CI | p | HR | 95 % CI | p | HR | 95 % CI | p | |
| Age | ||||||||||||
| < 66 years | 1 | 1 | 1 | 1 | ||||||||
| ≥ 66 years | 2.209 | 1.616–3.019 | <0.001 | 1.777 | 1.339–2.357 | <0.001 | 1.046 | 0.691–1.584 | 0.830 | 0.793 | 0.356–1.766 | 0.570 |
| Gender | ||||||||||||
| female | 1 | 1 | 1 | 1 | ||||||||
| male | 1.175 | 0.854–1.615 | 0.321 | 1.018 | 0.764–1.355 | 0.905 | 0.726 | 0.480–1.100 | 0.131 | 1.301 | 0.561–3.015 | 0.540 |
| BMI | ||||||||||||
| < 30 | 1 | 1 | 1 | 1 | ||||||||
| ≥ 30 | 1.05 | 0,740–1,489 | 0.784 | 0.869 | 0,624–1,212 | 0.408 | 0.799 | 0,482–1,326 | 0.385 | 1.162 | 0,485–2,782 | 0.737 |
| ASA | ||||||||||||
| I | 1 | 1 | 1 | 1 | ||||||||
| II | 2.384 | 1.191–4.772 | 0.014 | 1.960 | 1.093–3.513 | 0.024 | 2.019 | 0.860–4.741 | 0.107 | 1.887 | 0.429–8.313 | 0.401 |
| III | 3.504 | 1.757–6.989 | <0.001 | 2.789 | 1.559–4.988 | 0.001 | 2.401 | 1.015–5.675 | 0.046 | 1.632 | 0.352–7.560 | 0.531 |
| IV | 4.415 | 1.638–11.896 | 0.003 | 2.829 | 1.125–7.104 | 0.027 | 0.740 | 0.089–6.150 | 0.780 | x | x | x |
| Tumor localization | ||||||||||||
| colon | 1 | 1 | 1 | 1 | ||||||||
| rectum | 1.014 | 0.745–1.378 | 0.931 | 1.190 | 0.899–1.574 | 0.223 | 1.391 | 0.919–2.104 | 0.119 | 5.053 | 2.018–12.655 | 0.001 |
| pT stage | ||||||||||||
| 1 | 1 | 1 | 1 | 1 | ||||||||
| 2 | 1.169 | 0.500–2.731 | 0.719 | 1.686 | 0.754–3.770 | 0.204 | 5.597 | 0.716–43.729 | 0.101 | 1.135 | 0.103–12.524 | 1.135 |
| 3 | 2.092 | 1.020–4.294 | 0.044 | 2.572 | 1.258–5.256 | 0.010 | 7.666 | 1.200–62.589 | 0.032 | 2.764 | 0.369–20.712 | 0.323 |
| 4 | 2.398 | 1.116–5.151 | 0.025 | 3.058 | 1.435–6.514 | 0.004 | 12.487 | 1.683–92.645 | 0.014 | 2.328 | 0.260–20.835 | 0.450 |
| pN stage | ||||||||||||
| 0 | 1 | 1 | 1 | 1 | ||||||||
| 1 | 1.918 | 1.365–2.696 | <0.001 | 2.160 | 1.582–2.948 | <0.001 | 3.424 | 2,101–5,580 | <0.001 | 1.874 | 0,739–4,751 | 0.186 |
| 2 | 3.121 | 2.076–4.690 | <0.001 | 3.304 | 2.266–4.818 | <0.001 | 5.222 | 2.989–9.124 | <0.001 | 4.210 | 1.599–11.087 | 0.004 |
| Tumor differentiation | ||||||||||||
| well | 1 | 1 | 1 | 1 | ||||||||
| moderately | 0.991 | 0.711–1.381 | 0.957 | 0.967 | 0.713–1.313 | 0.831 | 1.194 | 0.747–1.907 | 0.459 | 1.373 | 0.514–3.670 | 0.527 |
| moderately | 1.909 | 1.200–3.036 | 0.006 | 1.937 | 1.263–2.971 | 0.002 | 2.140 | 1.123–4.078 | 0.021 | 4.952 | 1.654–14.824 | 0.004 |
| Surgical approach | ||||||||||||
| open | 1 | 1 | 1 | 1 | ||||||||
| laparoscopic | 0.786 | 0.580–1.067 | 0.123 | 0.894 | 0.676–1.182 | 0.432 | 1.390 | 0.901–2.142 | 0.136 | 0.699 | 0.319–1.534 | 0.372 |
| Duration of operation | ||||||||||||
| ≤ 150 minut | 1 | 1 | 1 | 1 | ||||||||
| > 150 minut | 1.136 | 0.838–1.539 | 0.411 | 1.258 | 0.953–1.661 | 0.106 | 1.357 | 0.897–2.053 | 0.148 | 1.652 | 0.749–3.644 | 0.214 |
| Blood loss | ||||||||||||
| ≤ 500 ml | 1 | 1 | 1 | 1 | ||||||||
| 501–1000 ml | 1.748 | 1.132–2.699 | 0.012 | 1.541 | 1.004–2.364 | 0.048 | 1.797 | 0.976–3.308 | 0.060 | 2.232 | 0.763–6.533 | 0.143 |
| > 1000 ml | 2.364 | 1.202–4.650 | 0.013 | 1.799 | 0.919–3.519 | 0.086 | 1.788 | 0.654–4.892 | 0.258 | 1.673 | 0.224–12.474 | 0.616 |
| Morbidity | ||||||||||||
| no | 1 | 1 | 1 | 1 | ||||||||
| yes | 2.139 | 1.554–2.944 | <0.001 | 1.756 | 1.302–2.369 | <0.001 | 1.422 | 0.896–2.258 | 0.135 | 1.160 | 0.463–2.908 | 0.752 |
| No. of transfusions | ||||||||||||
| 0 | 1 | 1 | 1 | 1 | ||||||||
| 1–2 | 1.020 | 0.662–1.573 | 0.928 | 0.924 | 0.608–1.405 | 0.712 | 0.793 | 0.407–1.543 | 0.495 | 1.584 | 0.584–4.293 | 0.366 |
| ≥ 3 | 3.409 | 2.250–5.164 | <0.001 | 3.404 | 2.324–4.984 | <0.001 | 2.941 | 1.649–5.246 | <0.001 | 2.403 | 0.702–8.224 | 0.162 |