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. 2011 Nov;90(5):855–865. doi: 10.1189/jlb.0211062

Figure 8. TRAIL regulates inflammatory neutrophil apoptosis.

Figure 8.

A proposed model for TRAIL regulating inflammation resolution by modulation of neutrophil lifespan. In WT mice, TRAIL expression by tissue cells, e.g., the respiratory epithelium, can induce apoptosis of recruited neutrophils. In TRAIL-deficient mice, inflammatory cell survival is prolonged until engagement of a constitutive program of neutrophil apoptosis. Exogenous TRAIL accelerates the apoptotic death of neutrophils in TRAIL-deficient and WT mice.