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. Author manuscript; available in PMC: 2013 May 4.

Published in final edited form as: Expert Opin Ther Targets. 2010 Feb;14(2):143–155. doi: 10.1517/14728220903540257

Modulation of endothelial KCa3.1 and KCa2.3 channel alters systemic blood pressure. A: Schematic illustration of the deleterious impact of KCa3.1/KCa2.3-deficiency on EDHF-dilations and blood pressure. B: Schematic illustration of the proposed blood pressure lowering effects of enhanced mRNA-expression of KCa2.3 or of pharmacological potentiation of KCa3.1 by SKA-31.

Modulation of endothelial KCa3.1 and KCa2.3 channel alters systemic blood pressure. A: Schematic illustration of the deleterious impact of KCa3.1/KCa2.3-deficiency on EDHF-dilations and blood pressure. B: Schematic illustration of the proposed blood pressure lowering effects of enhanced mRNA-expression of KCa2.3 or of pharmacological potentiation of KCa3.1 by SKA-31.