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Bar diagram showing the percentage block of 30 µM Hl15-1-1 on the different K+ channels tested (mean ± SEM). From each Shaker-related VGPC, a current trace in control (black) and in the presence of 30 μM Hl15-1-1 (red) is shown. Current recordings were elicited by a depolarizing step (0 mV for Kv1.3; +10 mV for Kv1.1 and Kv1.6; +30 mV for Kv1.5; +40 mV for Kv1.8 and + 60mV for Kv1.2) from a holding potential of 80 mV followed by a repolarization to −50 mV. Scale bars are given as inset.
