1.

Effects of anthocyanidins on the expression of CYP1A1 and CYP1A2 mRNAs in primary human hepatocytes treated for 24 h with tested compounds. Results are expressed as fold induction over the vehicle-treated cells. Data are mean ± S.D. from triplicate measurements. nd = not determined

COMPOUND	HH 44		HH 45		HEP220670
	CYP1A1	CYP1A2	CYP1A1	CYP1A2	CYP1A1	CYP1A2
DMSO	1.00 ± 0.06	1.00 ± 0.06	1.00 ± 0.36	1.00 ± 0.36	1.00 ± 0.14	1.00 ± 0.13
TCDD	159.79 ± 10.5	63.34 ± 0.93	330.84 ± 57.4	51.62 ± 9.13	229.13 ± 6.74	143.51 ± 0.70
cyanidin 10 µM	2.29 ± 0.07	4.71 ± 0.61	0.95 ± 0.26	1.42 ± 0.40	nd	nd
cyanidin 50 µM	2.11 ± 0.23	4.96 ± 1.35	0.96 ± 0.10	2.02 ± 0.26	1.80 ± 0.20	1.90 ± 0.21
malvidin 10 µM	0.90 ± 0.05	1.89 ± 0.01	1.51 ± 0.03	1.51 ± 0.06	nd	nd
malvidin 50 µM	1.35 ± 0.03	2.29 ± 0.08	1.83 ± 0.15	2.96 ± 0.38	1.11 ± 0.03	1.40 ± 0.05
delphinidin 10 µM	1.20 ± 0.20	2.47 ± 0.14	2.19 ± 0.27	1.99 ± 0.25	nd	nd
delphinidin 50 µM	0.96 ± 0.20	013 ± 0.02	1.16 ± 0.19	1.26 ± 0.38	1.13 ± 0.03	1.33 ± 0.02
peonidin 10 µM	1.64 ± 0.01	1.05 ± 0.05	0.84 ± 0.12	1.07 ± 0.13	nd	nd
peonidin 50 µM	3.52 ± 0.80	1.61 ± 0.19	1.11 ± 0.10	1.53 ± 0.13	1.57 ± 0.08	1.82 ± 0.08
petunidin 10 µM	1.40 ± 0.32	0.69 ± 0.01	2.58 ± 0.15	2.12 ± 0.14	nd	nd
petunidin 50 µM	2.35 ± 0.13	0.67 ± 0.02	1.48 ± 0.18	2.57 ± 0.29	1.13 ± 0.07	0.85 ± 0.03
pelargonidin 10 µM	14.62 ± 1.64	0.53 ± 0.02	3.43 ± 0.39	2.13 ± 0.25	1.59 ± 0.03	1.89 ± 0.04
pelargonidin 50 µM	22.24 ± 3.06	0.73 ± 0.07	15.3 ± 0.34	2.61 ± 0.11	5.90 ± 0.09	5.41 ± 0.06