Table 4.
Multivariable pattern mixture models
| |
“All Children” Model |
“Adolescent only” Model |
||
|---|---|---|---|---|
| β ( SE ) | p-value | β ( SE ) | p-value | |
| Intercept |
49.7 (4.1) |
<.0001 |
90.3 (13.5) |
<.0001 |
| Time |
|
|
|
|
| Baseline (reference) |
|
|
|
|
| 45 days |
-8.5 (2.4) |
.0003 |
-3.2 (3.4) |
0.35 |
| 3 months |
-8.0 (2.6) |
.002 |
-6.0 (3.7) |
0.11 |
| 6 months |
-4.8 (2.6) |
.07 |
-3.5 (4.1) |
0.39 |
| 12 months |
2.0 (4.8) |
.68 |
-0.1 (5.1) |
0.98 |
| Baseline timing |
-11.8 (2.7) |
<.0001 |
-14.3 (3.4) |
<.0001 |
| Time*Baseline timing |
|
|
|
|
| Baseline*baseline timing (reference) |
|
|
|
|
| 45 days*baseline timing |
7.5 (3.4) |
.03 |
8.6 (4.7) |
0.06 |
| 3 months*baseline timing |
6.8 (3.7) |
.07 |
9.7 (4.9) |
0.048 |
| 6 months*baseline timing |
11.5 (3.7) |
.002 |
11.7 (5.3) |
0.03 |
| 12 months*baseline timing |
9.6 (5.8) |
.10 |
8.8 (6.3) |
0.16 |
| Baseline parental emotional functioning for ½ SD changea |
3.8 (0.4) |
<.0001 |
2.2 (0.7) |
0.002 |
| Baseline parental emotional functioning*parent rater for ½ SD changea |
|
|
1.7 (0.6) |
0.003 |
| Child age |
-0.5 (0.2) |
.008 |
-1.7 (0.8) |
0.03 |
| Log duration of illness |
-1.2 (0.7) |
.07 |
|
|
| Transplant Type |
|
|
|
|
| Autologous |
4.2 (2.2) |
.06 |
|
|
| Allogeneic, related |
4.7 (2.0) |
.02 |
|
|
| Allogeneic, unrelated (reference) |
|
|
|
|
| Early complicationsb |
-1.8 (2.7) |
.49 |
-2.0 (3.4) |
0.57 |
| Time*early complicationsb |
|
|
|
|
| Baseline*early complications (reference) |
|
|
|
|
| 45 days*early complications |
-6.4 (3.4) |
.06 |
-10.1 (4.7) |
0.03 |
| 3 months*early complications |
2.3 (3.6) |
.52 |
-2.2 (4.9) |
0.66 |
| 6 months*early complications |
4.1 (3.8) |
.27 |
-3.3 (5.4) |
0.54 |
| 12 months*early complications |
0.3 (6.2) |
.96 |
-1.2 (6.3) |
0.85 |
| Late cGVHDc |
7.6 (7.7) |
.32 |
|
|
| Time*Late cGVHDc |
|
|
|
|
| Baseline*late cGVHD (reference) |
|
|
|
|
| 45 days* late cGVHD |
-12.5 (9.3) |
.18 |
|
|
| 3 months* late cGVHD |
-21.9 (9.7) |
.02 |
|
|
| 6 months* late cGVHD |
-20.0 (9.4) |
.03 |
|
|
| 12 months* late cGVHD |
-14.3 (10.5) |
.17 |
|
|
| Parent Female |
|
|
-1.5 (4.0) |
0.71 |
| Parent Rater |
|
|
-13.3 (4.6) |
0.004 |
| Parent female*Parent rater |
|
|
-6.6 (3.2) |
0.04 |
| Time*Parent rater |
|
|
|
|
| Baseline*parent rater (reference) |
|
|
|
|
| 45 days*parent rater |
|
|
-4.5 (2.4) |
0.054 |
| 3 months*parent rater |
|
|
-3.3 (2.4) |
0.18 |
| 6 months*parent rater |
|
|
-1.5 (2.7) |
0.57 |
| 12 months*parent rater | 1.1 (2.9) | 0.71 | ||
Abbreviations: SE standard error, SD standard deviation, cGVHD chronic graft versus host disease.
a A half standard deviation for the parent emotional functioning is equal to 9.5.
b Early complications refers to at least one of the following within the first 3 months: aGVHD of grade 2 or higher, intermediate or poor toxicity, or localized or systemic infection.
c Late cGVHD refers to limited or extensive cGVHD between 6 and 12 months.