Table 2.
Candidate genes from this study with human homologues implicated in normal and disordered sleep
| Human sleep trait or disorder | Human gene | Sleep trait | D. melanogastergene | References |
|---|---|---|---|---|
| Daytime sleepiness |
PDE4D |
Day average bout length |
dunce (dnc) |
[43] |
| |
|
Night sleep CVE |
|
|
| |
|
Waking activity CVE |
|
|
| |
EYA1 |
Day average bout length |
eyes absent (eya) |
[43] |
| |
|
Day bout number CVE |
|
|
| Usual bedtime |
OPCML |
Day average bout length |
CG31646 |
[43] |
| |
|
Night sleep CVE |
|
|
| |
|
Waking activity CVE |
|
|
| Sleep duration |
NCOA7 |
Waking activity |
l(3)82Fd |
[43] |
| |
|
Night sleep CVE |
|
|
| |
|
Waking activity CVE |
|
|
| Narcolepsy |
P2RY11 |
Day sleep CVE |
peter pan (ppan) |
[44] |
| |
TRIB2 |
Day bout number CVE |
tribbles (trbl) |
[45-47] |
| |
|
|
|
[48] |
| |
Dscam |
Day average bout length |
Down syndrome cell adhesion molecule (Dscam) |
[49] |
| Restless Leg Syndrome |
MEIS1 |
Waking activity |
homothorax (hth) |
[50] |
| |
|
Waking activity CVE |
|
|
| |
PTPRD |
Waking activity CVE |
Leukocyte-antigen-related-like (Lar) |
[51] |
| Sleep Apnea |
ApoE |
Night sleep |
nudE |
[52] |
| |
|
Day average bout length |
|
|
| Night sleep CVE |