Table 2.
Estimation of false negatives among 55 HMBS negative cases
| HPV marker |
Observed HPV positives among |
Chi-square test for association between observed HPV status and HMBS |
Estimated false negatives for HPV among 55 HMBS negative cases |
|||
|---|---|---|---|---|---|---|
| HMBS positive n = 83 | HMBS negative n = 55 | Number | As proportion of 55 HMBS negative cases | 95% confidence interval | ||
| GP5+/6+ PCR |
49 (59%) |
20 (36%) |
p = 0.009 |
12.5 |
23% |
6% to 38% |
| ISH |
42 (51%) |
18 (33%) |
p = 0.04 |
9.8 |
18% |
1% to 33% |
| p16 | 47 (57%) | 26 (47%) | p = 0.28 | 5.1 | 9% | 0%* to 26% |
For GP5+/6+ PCR, number of false negatives estimated as 49 × 55/83 – 20 = 12.5, representing 23% of HMBS negative cases. The same method was used to calculate false negative rates for ISH and p16.
*95% confidence interval extends below 0 for p16 – shown truncated here.