Table 4.

Prognostic ability of individual HPV detection methods

Group	p16	ISH	GP5+/6+ PCR
All cases (n = 138)	0.24 (0.15-0.39)	0.27 (0.16-0.46)	0.29 (0.18-0.47)
All cases excluding equivocals (n = 128)	0.22* (0.13-0.37)	0.25 (0.14-0.43)	0.26 (0.16-0.44)
HMBS positive cases (n = 83)	0.20 (0.10-0.37)	0.33 (0.18-0.62)	0.22 (0.12-0.41)
HMBS positive cases excluding equivocals (n = 78)	0.20* (0.10-0.38)	0.27 (0.14-0.53)	0.20 (0.10-0.38)

Hazard ratios (HR) for overall survival, with 95% confidence intervals, are shown for each HPV testing method.

* When ‘equivocal’ cases (with discrepant p16 and HPV DNA testing results) are excluded, analyses for p16 and the composite criterion for HPV positivity based on 3 markers are equivalent and represent the ‘gold standard’.