Table 5.
Second primary malignancy and recurrence (local/distant) by HPV status
|
HPV status |
All cases |
Site of recurrence |
Second Primary Malignancy (SPM) |
|||||
|---|---|---|---|---|---|---|---|---|
| None | H&N | DM | HN + DM | No SPM | SPM H&N | Other SPM | ||
|
‘True’ negatives (Group 1) p16 negative, PCR & ISH negative |
59 |
39 |
15 |
4 |
1 |
51 |
1 |
7 |
|
‘Equivocal' (Group 2) p16 negative, PCR &/or ISH positive |
6 |
4 |
1 |
1 |
0 |
5 |
0 |
1 |
|
‘True’ positives (Group 3) p16 positive, PCR &/or ISH positive |
69 |
57 |
8 |
4 |
0 |
61 |
3 |
5 |
|
‘Equivocal' (Group 4) p16 positive, PCR & ISH negative |
4 |
2 |
1 |
1 |
0 |
4 |
0 |
0 |
| Total | 138 | 102 | 25 | 10 | 1 | 121 | 4 | 13 |
Head and Neck (H&N), Distant Metastases (DM), Second Primary Malignancy (SPM).