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Host Notch4 deficiency delays onset of tumors derived from orthotopic transplantation of MMTV-PyMT cells. Incidence of palpable tumors in wild type and Notch4−/− mice at 1, 2 and 3 weeks post orthotopic transplantation of MMTV-PyMT tumor cells. Tumor onset is significantly delayed in Notch4−/− mice at the early time points.
