Table 2.
Summary of commonly used disease models for highly pathogenic members of the Filoviridae, Arenaviridae, Bunyaviridae and Paramyoviridae
| Mice (adult) | Guinea pig | Hamster | Nonhuman primates | |
|---|---|---|---|---|
| Filoviruses | ||||
| Ebola virus (Ebola hemorrhagic fever) |
Yes (adapted virus) | Yes (adapted virus) | Yes (adapted virus) | Cynomolgus and Rhesus macaques, Marmosets, Baboons, African Greens |
| Marburg virus (Marburg hemorrhagic fever) |
Yes (adapted virus) | Yes (adapted virus) | N.D. | Cynomolgus and Rhesus macaques, Marmosets, Baboons, African Greens |
| Arenaviruses | ||||
| Lassa virus (Lassa fever) |
Yes (IFNAR KO) | Yes (inbred) | N.D. | Cynomolgus and Rhesus macaques, Marmosets |
| Lujo virus | N.D. | Yes (inbred) | N.D. | N.D. |
| Junin virus (Argentine hemorrhagic fever) |
N.D. | Yes | N.D. | Rhesus macaques, Marmosets |
| Guanarito virus (Venezuelan hemorrhagic fever) |
N.D. | Yes | N.D. | N.D. |
| Machupo virus (Bolivian hemorrhagic Fever) |
Yes (STAT-1 KO) | Yes | N.D. | Cynomolgus and Rhesus macaques, African Greens |
| Sabia virus (Brazilian hemorrhagic fever) | N.D. | N.D. | N.D. | N.D. |
| Chapare virus | N.D. | N.D. | N.D. | N.D. |
| Bunyaviruses | ||||
| CCHFV (Crimean Congo hemorrhagic fever) | Yes (IFNAR/STAT-1 KO) | N.D. | N.D. | N.D. |
| SFTSV (Severe Fever with Thromocytopenia Syndrome) |
Yes | N.D. | N.D. | N.D. |
| Andes virus (Hantavirus pulmonary syndrome) |
N.D. | N.D. | Yes | N.D. |
| Paramyxoviruses | ||||
| Nipah virus (Nipah disease) |
N.D. | Yes | Yes | African Greens |
| Hendra virus (Hendra disease) |
N.D. | Yes | Yes | African Greens |
N.D. = none described.