Table 2b.
Fracture sequential analysis by time of extract using maximized sequential probability ratio test (MaxSPRT)
|
|
Near Real-Time Data Extraction |
1.5 Month Delay Data Extraction |
Final Pull (Nov 2009)α |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Observed | Cumulative |
Cumulative |
||||||||||
| Month | Exposed Days | Outcomes | Expected | RR | LLRβ | Exposed Days | Outcomes | Expected | RR | LLRβ | RR (95% confidence interval) | LLRβ |
|
|
|
|
|
|||||||||
| APR 2009 | 48,635 | 0 | 2.1 | 0 | 0 | 52,516 | 1 | 2.4 | 0.41 | 0 | ||
| MAY | 111,096 | 3 | 5.1 | 0.59 | 0 | 111,147 | 4 | 5.1 | 0.78 | 0 | ||
| JUN | 164,205 | 4 | 7.3 | 0.54 | 0 | 163,941 | 4 | 7.4 | 0.54 | 0 | ||
| JUL | 189,766 | 4 | 8.5 | 0.47 | 0 | 229,523 | 11 | 10.7 | 1.03 | 0.005 | ||
| AUG | 291,278 | 14 | 13.6 | 1.03 | 0.005 | 291,158 | 14 | 13.6 | 1.03 | 0.005 | ||
| SEP | 350,298 | 15 | 16.3 | 0.92 | 0 | 350,882 | 15 | 16.4 | 0.92 | 0 | ||
| OCT | 412,820 | 17 | 19.2 | 0.88 | 0 | - | - | - | - | - | 0.88 (0.46–1.31) | 0 |
Note: RR - Relative Risk; LLR - Log-likelihood Ratio
α
Nonsequential analysis using final pull.
β
Signal criteria for .05 alpha level of significance is a log-likelihood ratio of 3.7.