Table 1.
Human primary prostate epithelial cellular proteins differentially expressed due to lycopene treatment.
| Accession Number | Protein | Unique peptides | Fold Change (p ≤ 0.05) | Function |
|---|---|---|---|---|
| Cytosol/membrane (non-nuclear) | ||||
| Apoptosis | ||||
| IPI00021263 | Protein kinase C inhibitor protein 1 | 7 | 0.85±0.13 | Anti-apoptosis process |
| IPI00304925 | Heat shock 70 kDa protein 1A/1B | 6 | 0.88±0.10 | Anti-apoptosis process |
| IPI00025512 | Heat shock protein beta-1 | 4 | 0.90±0.04 | Anti-apoptosis process |
| IPI00003815 | Rho GDP-dissociation inhibitor 1 | 3 | 0.89±0.09 | Anti-apoptosis process |
| IPI00550900 | Translationally-controlled tumor protein | 2 | 0.90±0.07 | Anti-apoptosis process |
| IPI00220766 | Lactoylglutathione lyase | 4 | 0.87±0.01 | Anti-apoptosis process |
| IPI00003362 | 78 kDa glucose-regulated protein | 14 | 0.84±0.09 | Anti-apoptosis process |
| IPI00007074 | Tyrosyl-tRNA synthetase | 3 | 1.20±0.09 | Induction of apoptosis |
| IPI00011253 | 40S ribosomal protein S3 | 6 | 1.15±0.07 | Activation of caspase, induction of apoptosis |
| IPI00479186 | Pyruvate kinase isozymes M2 | 19 | 1.15±0.07 | Nuclear translocation induction of cell death |
| IPI00010896 | Chloride intracellular channel protein 1 | 6 | 0.65±0.05 | Suppression of CLIC1 which induces apoptosis and inhibits tumor growth |
| Antioxidation and cytoprotection | ||||
| IPI00386755 | ERO1-like protein alpha | 10 | 0.80±0.06 | Responsible for a significant proportion of reactive oxygen species (ROS) |
| IPI00642936 | Glutathione S-transferase omega 1 | 4 | 1.11±0.05 | Functions in the GSH-ascorbate cycle as part of antioxidant metabolism |
| IPI00009634 | Sulfide:quinone oxidoreductase | 8 | 1.13±0.06 | Catalyzes oxidation of hydrogen sulfide with the help of a quinone |
| IPI00640741 | Peroxiredoxin-1 | 7 | 1.14±0.09 | Reduces hydrogen peroxide and alkyl hydroperoxides |
| IPI00219757 | Glutathione S-transferase P 1 | 10 | 1.17±0.04 | Conjugates GSH with electrophiles |
| IPI00000877 | Hypoxia up-regulated protein 1 | 4 | 1.56±0.19 | Cytoprotective mechanisms triggered by oxygen deprivation |
| IPI00008223 | UV excision repair protein RAD23 homolog B | 3 | 1.49±0.35 | Recognizes helix-distorting lesions in DNA and initiates global genome repair |
| Signal transduction | ||||
| IPI00298547 | Protein DJ1 | 4 | 0.77±0.13 | Positive regulator of androgen receptor-dependent transcription |
| IPI00027230 | Heat shock protein 90 kDa beta 1 | 9 | 0.89±0.08 | AR chaperon protein which stabilize AR in the cytosol |
| IPI00646689 | Thioredoxin domain-containing protein 17 | 3 | 0.87±0.07 | Deficiency enhances TNF-alpha induced apoptosis |
| IPI00293276 | Macrophage migration inhibitory factor | 2 | 0.76±0.04 | Proinflammatory cytokine, positive regulation of ERK1 and ERK2 cascade |
| IPI00022078 | Protein NDRG1 | 4 | 1.42±0.21 | Act as tumor suppressor in many cell types |
| IPI00411765 | Epithelial cell marker protein 1 | 7 | 0.88±0.08 | Regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway |
| Nucleus | ||||
| IPI00021405 | Prelamin-A/C | 7 | 0.84±0.14 | Disrupts mitosis and induces DNA damage |
| IPI00411765 | Epithelial cell marker protein 1 | 7 | 0.84±0.08 | Regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway |