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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Invest Dermatol. 2013 Jan 16;133(6):1655–1665. doi: 10.1038/jid.2013.16

Figure 4. Blood clot formation plays no role in the re-epithelialization process.

Figure 4

Methylene blue penetration assay (a-d) and H&E stained longitudinal sections (e-l) of wounds from control fish (a, c, e, f, i, j) and fish treated with 150 μM Sodium Warfarin (b, d, g, h, k, l), demonstrating no differences in the degree of barrier recovery or wound re-epithelialization at 7 hpw (a, b, e-h) or 24 hpw (c, d, i-l) (n=18/18), even though warfarin-treated fish show localized internal bleeding, particularly around the mouth, gills and pec fins at 7 and 24 hpw (m-p). Scale bars: a-d = 1 mm; e-l = 100 μm.