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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Neuropharmacology. 2013 Mar 5;70:316–323. doi: 10.1016/j.neuropharm.2013.02.014

Figure 4. Pretreatment of both CRFR1 and CRFR2 antagonists are required for blockade of CRF effect on spontaneous glutamatergic transmission in the CeAL.

Figure 4

(A) Bar graph summarizing the effects of CRFR1 and CRFR2 antagonist pretreatment on basal sEPSC frequency. (B) Line-graph summarizing the effect of CRFR1 and R2 antagonist pretreatment on subsequent effect of CRF. Note that only combined pretreatment with CRFR1 and CRFR2 antagonists could significantly reduce the effect of CRF on sESPC frequency. Dotted line indicates normalized baseline values. * indicates significant difference between groups (p<0.05).