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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Pain. 2013 Mar 15;14(5):467–474. doi: 10.1016/j.jpain.2012.12.015

Figure 3.

Figure 3

A moderate 3.0:1 KD formulation produces hypoalgesia which persists through 10–11 weeks of feeding. Separate groups of rats were challenged with a daily incremental 6-temperature test after 2 or 10 weeks on the 3.0:1 KD. Top and bottom X-axes indicate hotplate temperature and days on diet, respectively. Group I was tested from 14–19 days, and the diet had significant effects at 49 and 50°C: Diet F=9.4, p=0.005; Temperature F=205.5, p<0.001; Interaction F=3.0, p=0.013; n=18–20. Group II was tested from 70–75 days, and the diet had significant effects at 48, 49 and 50°C: Diet F=10.5, p=0.003; Temperature F=172.6, p<0.001; Interaction F=4.4, p<0.001; n=17–19. *p<0.05, **p<0.01, ***p<0.001 compared to CD at corresponding temperatures.