Figure 4.
KDs transiently and minimally affected locomotion and spatial memory in the Y-maze. Top: Locomotion decreased over repeated testing in all groups, but was increased with both KDs at one week of feeding compared to controls; this difference was no longer present at two weeks. Bottom: The accuracy of spontaneous alternations significantly increased at two weeks of feeding with the 6.6:1 KD; this effect was not present with the 3.0:1 KD. Dashed line indicates level for random arm entries. Locomotion: Time F=60.7, p<0.001; Interaction F=2.6, p=0.041. Memory: Interaction F=2.5, p=0.047; n=17–18. *p<0.05 compared to CD at corresponding time.